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A new phase in the battle against the coronavirus and the beginning of Joe Biden's presidency will dominate the news this year, but there will be plenty of other changes ahead that will shape our lives, too.

  • Here’s what Axios’ newsletter authors and expert reporters will be watching — from the future of the economy and Big Tech's antitrust fights to the next stages in developing artificial intelligence and biotechnology. (Sign up for their newsletters here.)

Politics: Leaving aside foreign policy unknowns, the success of the Biden presidency depends on his ability to achieve compromise with his old colleagues in the Senate. Yes, he knows the rhythms and the rules, but he's only served with about a third of current senators. He may be speaking a language that has fundamentally changed since he's left the body. — Hans Nichols

Business: We're watching to see if the real economy and capital markets will narrow their wild divergence. Maybe that means stocks pull back a bit, or maybe vaccines spark this millennium’s version of the Roaring ‘20s (which came just after the 1918 Pandemic). — Dan Primack

Tech: A flurry of antitrust lawsuits against Google and Facebook ended 2020 and will set the agenda for the new year. One big question: Whether additional actions against Apple and/or Amazon follow. — Ina Fried

Media: Throughout the pandemic, local news took a severe hit, with most outlets having to lay off staff, consolidate, or shed historic parts of their legacy, like print products and newsrooms. In 2021, we'll be on the lookout for whether new commercial investments can start to rebuild the local news ecosystem in a more sustainable way. ...

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